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The Flipping 50 Show

Let's start Flipping 50 with the energy and the vitality you want for this second half! I solve your biggest challenges and answer questions about how to move, what to eat, and when, along with the small lifestyle changes that can make the most difference in the least amount of time. Join me and my expert guests for safe, sane, simple solutions for your second (and better) half!

Jan 26, 2024

You lift the weights, drop the collagen in your coffee and hydrate like it’s your job but still with the toned muscles see loose skin. A female scientist may have the answer for crepey skin. 

In 2018 I received hundreds of applications for the Flipping50TV show Popular questions made it to the show. The 18th episode (of the 39 done in 3 seasons) was literally about crepey skin. In the letter it was from a woman who’d experienced significant weight loss, yet her loose skin was an issue. She’s not alone. Even without weight loss, at some moment post menopause when that estrogen needle bonks, almost all women notice a difference. 

But some seem to have it figured out. Not all women 60 or 65 or 70 have the same skin. So what’s the difference? Lifestyle habits matter. And for secret weapons, this episode shares a relatively new discovery.

Tackling the Solution for Crepey Skin

In this engaging podcast episode, Dr. Alessandra, the Co-Founder and Chief Scientific Officer of OneSkin, dives deep into the world of skin longevity.

A Flipping 50 TV Episode Offers a Solution for Crepey Skin:


My Guest:  

Dr. Alessandra is the Co-Founder and Chief Scientific Officer of OneSkin, a disruptive and fast-growing skin longevity company developing products to address the root causes of aging so that skin functions, feels, and appears younger.

The company was founded by a team of 4 female PhD-level longevity scientists with 15+ years of experience in stem cell biology, skin regeneration, aging, and bioinformatics. They started building a skin aging platform to validate products in the market. After they discovered that many anti-aging skincare products are not only ineffective but often accelerate the aging process and compromise skin’s health, they set a screening platform to identify new molecules that could target the root causes of skin aging. 

Dr. Alessandra led the team that identified the OS-01, the world’s first cosmetic peptide that reverses aging at the molecular level, showed significant improvement in skin health and appearance in 100% of users, according to a third party clinical study.

OneSkin has gained recognition from key opinion leaders in longevity science, including foremost authority on biohacking Dave Asprey, world-renowned aging research doctor David Sinclair, and Tony Robbins. They have also been featured in many leading media outlets like CNN, Forbes, LA Weekly, and US Insider.

Dr. Alessandra holds a Master’s degree in stem cell biology and a PhD in skin regeneration and tissue engineering from the Federal University of Minas Gerais in Brazil. She led the OneSkin team that discovered a new molecule, OS-01, capable of reducing the skin’s biological age. 

Dr. Alessandra is also the co-inventor of five patents and has published 20 peer-reviewed papers in scientific journals.

Questions We Answer in This Episode:

  • What are the greatest contributors to skin aging – and do they differ from aging in general?
  • You also discovered that certain products on the market targeting women actually accelerate aging – the very ones we’re putting on our skin to help .. every woman listening wants to know if she has something on her bathroom counter that accelerates the aging process! 
  • The skin aging science behind OneSkin product results such as improving skin barrier, evenness, elasticity, reducing wrinkles, and ultimately, the skin biological age.
  • What prompted you to move from academia (college, Master’s, PhD, and post-doc) to running a disruptive startup?  that aims to be the first to deliver true skin rejuvenation. How did the discovery or development of OS-01 happen?
  • How old are you and how have you personally used the products? Did you first begin to experiment with your own skin? How do you use the products? 


Other Episodes You Might Like: 

Your Hormones and Skin in Midlife | Interview with TheSpaDr

Acne in Menopause? How to Deal with It | Interview with a Skin Expert